I would say that ordinary people should not do the ketogenic diet to lose weight, unless patients with severe metabolic syndrome do it under the guidance of a doctor (because the benefits outweigh the harm).
It was found that the average life span of people who had long-term high or low carbohydrate intake was lower than that of those who ate a normal diet. Recently, research published in Science Advances provides more evidence: the ketogenic diet can induce the accumulation of senescent cells in multiple organs and tissues such as the heart and kidneys, and this effect is through adenosine monophosphate-activated protein kinase (AMPK). And the inactivation of MDM2 leads to the accumulation of p53 and the production of p21, further inducing the occurrence of cellular senescence.
A healthy lifestyle and a balanced diet is good for life.