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Long-term continuation of a ketogenic diet may lead to cellular senescence in normal organs and tissues, especially the heart and kidneys. However, the intermittent ketogenic diet did not show the pro-inflammatory effect caused by senescent cells. We need to take a break from the ketogenic diet, otherwise there may be long-term consequences. This study also shows that the ketogenic diet The beneficial effects may be enhanced by planned rest. The cellular senescence induced by the ketogenic diet can be eliminated by the senescent cell scavenger Senolytic. In addition, the intermittent ketogenic diet can also prevent the induction of cellular senescence.