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Glucosamine is a natural component of glycosaminoglycans found in the cartilage and synovial fluid of the joint. It is a factor in maintaining healthy cartilage and joint health. Glucosamine helps protect against the deterioration of cartilage. As such, glucosamine helps relieve joint pain associated with osteoarthritis (of the knee). Chondroitin sulfate is one of the primary components of cartilage and helps relieve joint pain associated with osteoarthritis (of the knee).